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07/01/2022 6:57 pm
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DNA is a polymer of nucleotides which are linked to each other by 3′-5′ phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose?
(a) Replace purine with pyrimidines
(b) Remove/Replace 3′ OH group in deoxy ribose
(c) Remove/Replace 2′ OH group with some other group in deoxy ribose
(d) Both ‘b’ and ‘c’.
1 Answer
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07/01/2022 6:58 pm
Correct answer: (b) Remove/Replace 3′ OH group in deoxy ribose
Explanation:
DNA is a polymer of nucleotides which are linked to each other by 3′-5′ phosphodiester bond. Remove/replace 3’ OH group in deoxyribose, to prevent polymerisation of nucleotides.