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When we talk of functional macromolecules (e.g., proteins as enzymes, hormones, receptors, antibodies etc.), towards what are they evolving?

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When we talk of functional macromolecules (e.g., proteins as enzymes, hormones, receptors, antibodies etc.), towards what are they evolving?

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Similarities in proteins and genes performing a given function among diverse organisms give clues to common ancestry. These biochemical similarities point to the same shared ancestry as structural similarities among diverse organisms. Trypsin (ancient enzyme) is present from protozoa to mammals.

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