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Illustrate the design of a bioreactor. Highlight the difference between a flask in your laboratory and a bioreactor which allows cells to grow in a continuous culture system.

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Illustrate the design of a bioreactor. Highlight the difference between a flask in your laboratory and a bioreactor which allows cells to grow in a continuous culture system.

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Small volume cultures cannot yield appreciable quantities of products. To produce in large quantities, the development of bioreactors, where large volumes (100-1000 litres) of culture can be processed, was required. Thus, bioreactors can be thought of as vessels in which raw materials are biologically converted into specific products, individual enzymes, etc., using microbial plant, animal or human cells. A bioreactor provides the optimal conditions for achieving the desired product by providing optimum growth conditions (temperature, pH, substrate, salts, vitamins, oxygen).

Simple stirred-tank bioreactor
Flask:
1. Flask is used to small laboratory scale testing of a culture.
2. Small volume cultures cannot yield appreciable quantities of products.
Bioreactor:
1. Bioreactor is used for commercial scale production.
2. To produce in large quantities the development of bioreactors, where large volumes (100-1000 litres) of culture can be processed, was required.
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