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Consult the internet and find out how to make orally active protein pharmaceuticals. What is the major problem to be encountered?

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Consult the internet and find out how to make orally active protein pharmaceuticals. What is the major problem to be encountered?

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The problem is stomach enzymes and acids. Once you orally ingest a protein, the proteases in your stomach juices (trypsin, chymotrypsin, pepsin) will cleave the holy-hell out of your therapeutic protein and the acids will denature whatever’s left beyond all recognition. This is why proteins like insulin have to be injected.

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