When the microbes affect the entire organ, such as lungs or kidneys, it is known as organ-specific manifestation. The microorganisms that enter the body travel to a specific organ and multiply there. Different microbes are at home in different parts of the body. For instance, Mycobacterium tuberculosis is the bacteria that cause tuberculosis.

When the entire tissue is affected by the microbes, it is called a tissue-specific manifestation. The immune system is also activated in response to the infections. The microorganisms enter into the tissues and damage it. The immune system recruits the disease-causing microbes and destroys them. This is known as inflammation.