(i) Menarche marks the beginning of the reproductive cycle of a female whereas menopause marks the end of the reproductive cycle.

(ii) Menarche generally takes place at puberty, i.e., at the age of 12-16 years while menopause takes place around the age of 45-50 years.

(iii) After menarche, there is an increased amount of production of female sex hormones whereas after menopause, the secretion of female sex hormones declines and sometimes completely stops.