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Assuming that the buffer in the blood is CO2 - HCO3- Calculate the ratio of conjugate base to acid necessary to maintain blood at its proper pH of 7.4.

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Assuming that the buffer in the blood is CO2 - HCO3- Calculate the ratio of conjugate base to acid necessary to maintain blood at its proper pH of 7.4.

K1(H2CO3) = 4.5 × 10-7

(a) 11

(b) 8

(c) 6

(d) 14

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Correct answer: (a) 11

Explanation:

CO2 with H2O forms H2CO3

CO2 + H2O ⇌ H+ + HCO3-

K1 = \(\frac{[H^+][HCO_3^-]}{[CO_2]}\)

= 4.5 x 10-7

Again pH = -log[H+] = 7.4

∴ [H+] = 4.0 x 10-8

∴ \(\frac{[HCO_3^-]}{[CO_2]}\)

= \(\frac{4.5 \times 10^{-7}}{4 \times 10^{-8}}\) = 11

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