Lathyrism which is caused by consumption of Khesari dal is a disease characterised by

(1) mental retardation, delay in the onset of puberty and cardiovascular abnormalities

(2) reproductive failure, susceptibility to diabetes mellitus and skeletal abnormalities

(3) gross skeletal deformation and thinning of collagen fibres and fibrils

(4) retardation of body growth, precocious puberty and renal dysfunction